Amyloid beta-Protein Fragment 25-35, >=97% (HPLC)

Amyloid beta-Protein Fragment 25-35, >=97% (HPLC)

Amino Acid Sequence

Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met

Application

Amyloid ?-Protein Fragment 25-35 has been used:to induce neurotoxicity in cortical culturesto induce Alzheimer?s disease in rat modelto induce apoptosis in mesenchymal stem cells (MSCs)

Biochem/physiol Actions

Amyloid ?-Protein Fragment 25-35 (A?25-35) is involved in the pathogenesis of Alzheimer?s disease. Inhibitors of this transition may serve as a potential agent in managing Alzheimer?s disease. It is present in the subiculum and entorhinal cortex neurons of Alzheimer?s brain samples and inclusion-body myositis (IBM) muscle. It binds to receptors present in microglia and is capable of lipid membrane insertion. The functional domain sequence of A? comprising of sequence GSNKGAIIGLM elicits neurotrophic and neurotoxic effects. A?25-35 exhibits rapid aggregation and displays age dependant neurotoxicity.

General description

Amyloid ?-Protein Fragment 25-35 (A?25-35) is derived from the amyloid-? protein.amyloid-? protein, which is mapped to human chromosome 21q21. A?25-35 lacks the N-terminal domain and the metal binding site and is majorly generated by proteolytic cleavage of A?(1?40) peptides. It has a ?-sheet and ?-turn structure.

Other Notes

Lyophilized from 0.1% TFA in H2O

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Code Description Quality Level InChI key InChI Manufacturer Composition Form Assay Price Quantity
3589535 Amyloid beta-Protein Fragment 25-35, >=97% (HPLC) 200 WIHBNMPFWRHGDF-UHFFFAOYSA-N 1S/C45H81N13O14S/c1-9-24(5)36(43(69)50-21-35(63)52-29(17-23(3)4)40(66)55-28(45(71)72)14-16-73-8)58-44(70)37(25(6)10-2)57-38(64)26(7)51-34(62)20-49-39(65)27(13- SIGMA-ALDRICH Protein Content, ≥80% powder ≥97% (HPLC)
£281.36 (exc VAT) per 1MG
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3589536 Amyloid beta-Protein Fragment 25-35, >=97% (HPLC) 200 WIHBNMPFWRHGDF-UHFFFAOYSA-N 1S/C45H81N13O14S/c1-9-24(5)36(43(69)50-21-35(63)52-29(17-23(3)4)40(66)55-28(45(71)72)14-16-73-8)58-44(70)37(25(6)10-2)57-38(64)26(7)51-34(62)20-49-39(65)27(13- SIGMA-ALDRICH Protein Content, ≥80% powder ≥97% (HPLC)
£92.63 (exc VAT) per 250UG
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