Thyroglobulin from bovine thyroid, powder, >=90% (agarose gel electrophoresis)

Thyroglobulin from bovine thyroid, powder, >=90% (agarose gel electrophoresis)

Application

Often used as a carrier protein for the production of antibodies. Its advantage is the large number of tyrosine residues that can be used for conjugation using the diazo reaction.

Bovine thyroglobulin was shown to stimulate proliferation in rat thyroid follicular cells as well as in primary porcine thyroid epithelial cells. This effect was mediated through PI3K signaling.

Biochem/physiol Actions

Bovine thyroglobulin is a large, tetrameric glycoprotein produced in the thyroid gland as a precursor to thyroid hormones. Its large size and absence from plasma under normal conditions makes it very immunogenic and reduces the chance that antibodies to this carrier protein will cross-react with plasma proteins in immunoassays. Haptens may be conjugated to thyroglobulin via accessible secondary amines.

Iodine-containing protein that is stored in the thyroid gland. Converted into circulating thyroxines when the thyroid is stimulated by thyroid-stimulating hormone (TSH) from the pituitary. Because its expression is unique to the thyroid, it is a sensitive indicator of recurrence or metastasis of thyroid cancer that has been treated by thyroid ablation.

Packaging

100, 500 mg in poly bottle

1, 5 g in poly bottle

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Code Description Manufacturer Composition Form Assay Price Quantity
3593696 Thyroglobulin from bovine thyroid, powder, >=90% (agarose gel electrophoresis) SIGMA-ALDRICH Iodine, ≥0.20% powder ≥90% (agarose gel electrophoresis)
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3593697 Thyroglobulin from bovine thyroid, powder, >=90% (agarose gel electrophoresis) SIGMA-ALDRICH Iodine, ≥0.20% powder ≥90% (agarose gel electrophoresis)
Click Add to Quote for price and delivery
-
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3593698 Thyroglobulin from bovine thyroid, powder, >=90% (agarose gel electrophoresis) SIGMA-ALDRICH Iodine, ≥0.20% powder ≥90% (agarose gel electrophoresis)
Click Add to Quote for price and delivery
-
+
3593699 Thyroglobulin from bovine thyroid, powder, >=90% (agarose gel electrophoresis) SIGMA-ALDRICH Iodine, ≥0.20% powder ≥90% (agarose gel electrophoresis)
Click Add to Quote for price and delivery
-
+