Hemocyanin from Megathura crenulata (keyhole limpet),

Hemocyanin from Megathura crenulata (keyhole limpet),

Application

Keyhole limpet hemocyanin (KLH) is a strong and well known immune-stimulant in both experimental animals and humans. It has been used as a hapten carrier protein to enhance antigen-specific T cell priming and is known to stimulate a CD4+ T-cell response. Hemocyanins stimulate Th1 reactions without known side effects, which make them ideal for long-term continuous treatment of cancer.

General description

Hemocyanin is a high molecular weight copper containing glycoprotein. It reversibly binds oxygen and forms the extra-cellular respiratory protein of mollusks. Keyhole limpet hemocyanin (KLH) is filtered from the hemolymph of Megathura crenulata, also called the giant keyhole limpet. It is native to the southern California coast and Mexico.

Gastropod hemocyanins are massive glycoproteins (4 to 8 MDa) designed by an intricate arrangement of 10 subunits that are self-assembled into hollow cylinders 35 nm in diameter.

Physical form

Lyophilized with stabilizing buffer

Reconstitution

Reconstitute with deionized water to a KLH concentration of 10 mg/mL, to yield an opalescent solution in 31 mM sodium phosphate buffer, pH 7.4, containing 0.46 M NaCl, 2% PVP and 41 mM sucrose. Reconstituted protein solution may be stored up to 2 months at −20?°C.

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Code Description Quality Level Manufacturer Technique(s) Storage Temp. Solubility Form Price Quantity
3591463 Hemocyanin from Megathura crenulata (keyhole limpet), 300 SIGMA-ALDRICH ELISA: suitable 2-8°C H2O: soluble powder
£198.14 (exc VAT) per 20MG
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3591465 Hemocyanin from Megathura crenulata (keyhole limpet), 300 SIGMA-ALDRICH ELISA: suitable 2-8°C H2O: soluble powder
£681.29 (exc VAT) per EACH
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