Cecropin A, >=97% (HPLC), powder
Amino Acid Sequence
Lys-Trp-Lys-Leu-Phe-Lys-Lys-Ile-Glu-Lys-Val-Gly-Gln-Asn-Ile-Arg-Asp-Gly-Ile-Ile-Lys-Ala-Gly-Pro-Ala-Val-Ala-Val-Val-Gly-Gln-Ala-Thr-Gln-Ile-Ala-Lys-NH2
Application
Cecropin A has been used as an antimicrobial peptide (AMP): to test its cytotoxic effect on breast adenocarcinoma (MDA-MB-231) and human mesothelioma (M14K) cell linesin ultrasensitive radial diffusion assay against E coli to test Galleria mellonella protein 24 and apolipophorin III effectsto test its minimal inhibitory concentrations (MICs) in sensitivity assay for Photorhabdus variants
Biochem/physiol Actions
Cecropin A interacts with cell membranes and makes it permeable for electrolytes. Cecropin A thus, favors cytolysis and finally cell death in the hepatocellular carcinoma and lymphoma. The synthetic cecropin A in transgenic rice confers protection against bacterial as well as fungal pathogens.
Antibacterial peptide originally identified in moths (Hyalophora cecropia) and later in pig intestine.
General description
Cecropin A belongs to cecropin class and comprises 37 amino acid residues in L configuration. Structurally, this peptide has a C-terminal hydrophobic ?-helical structure and the amphipathic N-terminal end. Cecropin A is linear and cationic in nature.
Other Notes
Lyophilized from 0.1% TFA in H2O
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