Gly-Pro-Arg-Pro, >=97% (HPLC)

Gly-Pro-Arg-Pro, >=97% (HPLC)

Amino Acid Sequence

Gly-Pro-Arg-Pro

Application

Gly-Pro-Arg-Pro (GPRP) has been used for the formation of crystal composed of GPRP and the 30kDa C-terminal fragment from the ? chain of fibrinogen (rFbg?C30), cloned and expressed in Pichia pastoris.

Biochem/physiol Actions

Gly-Pro-Arg-Pro peptide suppresses the early steps of fibrin polymerization. The amide derivative of this peptide prevents the degradation of fibrinogen and fragment D by plasmin, even in the presence of EGTA (ethylene glycol-bis (?-aminoethyl ether)-N,N,N?,N?-tetraacetic acid).

Gly-Pro-Arg-Pro (GPRP) is capable of increasing free thrombin. Thus it can be utilized to make thrombin-degranulated platelets, which helps in studying platelet reactions.

Inhibits fibrin polymerization.

General description

Gly-Pro-Arg-Pro is a peptide that mimics the N-terminal Gly-Pro-Arg region in the ? chain of fibrin protein.

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Code Description Quality Level InChI key InChI Manufacturer Storage Temp. Assay Price Quantity
3591280 Gly-Pro-Arg-Pro, >=97% (HPLC) 200 WXPZDDCNKXMOMC-AVGNSLFASA-N 1S/C18H31N7O5/c19-10-14(26)24-8-2-5-12(24)15(27)23-11(4-1-7-22-18(20)21)16(28)25-9-3-6-13(25)17(29)30/h11-13H,1-10,19H2,(H,23,27)(H,29,30)(H4,20,21,22)/t11-,12 SIGMA-ALDRICH −20°C ≥95% (HPLC)
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3591281 Gly-Pro-Arg-Pro, >=97% (HPLC) 200 WXPZDDCNKXMOMC-AVGNSLFASA-N 1S/C18H31N7O5/c19-10-14(26)24-8-2-5-12(24)15(27)23-11(4-1-7-22-18(20)21)16(28)25-9-3-6-13(25)17(29)30/h11-13H,1-10,19H2,(H,23,27)(H,29,30)(H4,20,21,22)/t11-,12 SIGMA-ALDRICH −20°C ≥95% (HPLC)
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