Urotensin II human, >=97% (HPLC), synthetic

Stock Code: 3593826
Manufacturer Part No: U7257-.5MG
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Amino Acid Sequence


Glu-Thr-Pro-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val [Disulfide Bridge: 5-10]


Application


Urotensin II human was used in agonist and antagonist preparation for calcium mobilization assay. The product can also be used as a test compound for studying the impact of dihydropyridine calcium antagonist amlodipine in human internal mammary artery and clinical implications.


Biochem/physiol Actions


Human urotensin II is a vasoactive neuropeptide that belongs to CRF family and stimulates arterial smooth muscle contraction, actin stress fiber formation and proliferation via small GTPase RhoA and there downstream effector Rho-kinase activation.The product is also a selective and potent vasoconstrictor agent as well as an agonist for the orphan receptor GPR14.


A neuroendocrine peptide of the CRF family that was originally isolated from fish brain but is also found in mammalian brain and spinal motor neurons. It is a potent vasoconstrictor. It may be a mediator of stress-induced anorexia.


Other Notes


Lyophilized from 0.1% TFA in H2O


Packaging


0.5, 1 mg in poly bottle

Quality Level200
InChI keyHFNHAPQMXICKCF-USJMABIRSA-N
InChI1S/C64H85N13O18S2/c1-33(2)52(64(94)95)75-61(91)48-32-97-96-31-47(73-59(89)46(29-51(82)83)72-62(92)49-17-11-25-77(49)63(93)53(34(3)78)76-54(84)40(66)22-23-50(80
ManufacturerSIGMA-ALDRICH
Formlyophilized powder
Assay≥97% (HPLC)

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