Urocortin rat, >=97% (HPLC), powder

Stock Code: 3593825
Manufacturer Part No: U6631-1MG
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£705.84 (exc VAT) per 1MG
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Amino Acid Sequence


Asp-Asp-Pro-Pro-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2


Application


Urocortin rat can be used for western blotting. The product can also be used for studying that whether CRF receptor type 2 (CRF2) and its high-affinity ligand, urocortin 1 (Ucn1) can mediate sex-specific cellular stress responses by using corticotropin-releasing factor receptor 2-deficient (Crhr2-/- ) and wild-type (WT) mice.


Biochem/physiol Actions


Urocortin is a CRF-related neuropeptide that binds to CRF receptor types 1?, 2? and 2?. It possesses appetite-suppressing effect. Urocortin along with corticotropin-releasing factor (CRF) binding protein (CRF-BP) enhances the free CRF levels in human brain by displacing hCRF from the binding protein.


Binds to CRF receptor types 1, 2α, and 2β; stimulates cAMP accumulation from cells transfected with these receptors. Acts in vitro to release ACTH from rat anterior pituitary cells.


Other Notes


Lyophilized from 0.1% TFA in H2O


Preparation Note


Urocortin rat dissolves in 1% acetic acid at 1 mg/ml to yield a clear, colorless solution.

Quality Level200
ManufacturerSIGMA-ALDRICH
Technique(s)western blot: suitable
Storage Temp.−20°C
Solubility1% acetic acid: >1 mg/mL, clear, colorless
Formpowder
Assay≥97% (HPLC)

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