Secretin human, >=97% (HPLC), powder

Secretin human, >=97% (HPLC), powder

Stock Code: 3592220
Manufacturer Part No: S7147-250UG
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Amino Acid Sequence

His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Glu-Gly-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2

Application

Secretin human has been used:in the radioimmunoassay with oxyntomodulinto test its effect on the enlargement and swelling of human endoderm stem cells (hEnSCs) derived cystto stimulate human induced pluripotent stem cells (iPSC)-derived biliary cells in cyclic adenosine monophosphate (cAMP) assays to test its effect on cAMP production

Biochem/physiol Actions

Stimulates secretion of carbonate-rich pancreatic fluid; relaxes smooth muscle

Secretin regulates the secretion of gastric acid and pancreatic bicarbonates. It serves as an antidiuretic hormone in the neurohypophysial-renal axis and participates in osmoregulation. Secretin mediates its function through the G-protein coupled secretin receptors. It regulates the pH of the duodenal by modulating gastric acid secretion.

General description

Secretin is a gastrointestinal hormone and a neuropeptide. It is synthesized from a precursor protein and shares sequence homology with other secretin family proteins like glucagon and vasoactive intestinal peptide (VIP).

Packaging

1 mg in serum bottle

250 µg in serum bottle

Quality Level200
InChI keyOWMZNFCDEHGFEP-NFBCVYDUSA-N
InChI1S/C130H220N44O40/c1-60(2)43-81(120(208)173-100(66(13)14)103(134)191)153-95(183)54-149-106(194)77(31-35-92(132)180)159-116(204)84(46-63(7)8)166-118(206)85(47-6
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
Formpowder
Assay≥97% (HPLC)

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