Secretin human has been used:in the radioimmunoassay with oxyntomodulinto test its effect on the enlargement and swelling of human endoderm stem cells (hEnSCs) derived cystto stimulate human induced pluripotent stem cells (iPSC)-derived biliary cells in cyclic adenosine monophosphate (cAMP) assays to test its effect on cAMP production
Biochem/physiol Actions
Stimulates secretion of carbonate-rich pancreatic fluid; relaxes smooth muscle
Secretin regulates the secretion of gastric acid and pancreatic bicarbonates. It serves as an antidiuretic hormone in the neurohypophysial-renal axis and participates in osmoregulation. Secretin mediates its function through the G-protein coupled secretin receptors. It regulates the pH of the duodenal by modulating gastric acid secretion.
General description
Secretin is a gastrointestinal hormone and a neuropeptide. It is synthesized from a precursor protein and shares sequence homology with other secretin family proteins like glucagon and vasoactive intestinal peptide (VIP).