S-Nitroso-N-acetyl-DL-penicillamine (SNAP) has been used:as a positive control in nitrite generation assay.to block the activity of endogenous transglutaminase (TG2).in proliferation assays to generate nitric oxide (NO) in cell cultures.
SNAP, a nitrosothiol derivative, releases nitric oxide (NO.) under physiological conditions thus making it a useful tool for studying pharmacological and physiological actions of NO. Because of its NO releasing properties SNAP is a potent vasodilator in vitro and in vivo and is less prone to produce pharmacological tolerance.