S-(5-Adenosyl)-L-methionine p-toluenesulfonate salt,;, from yeast (L-methionine enriched), >=80% (HP
Application
S-(5?-Adenosyl)-L-methionine p-toluenesulfonate salt has been used for cell proliferation assay. It has also been used for methylation assay.
Biochem/physiol Actions
Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.
S-(5′-Adenosyl)-L-methionine (SAM) is anti-apoptotic in normal hepatocytes and normal colon epithelial cells but pro-apoptotic in liver human hepatocellular carcinoma (HCC), HepG2 cells and colon cancer cells.
Caution
This material is unstable at room temperature.
General description
S-(5?-Adenosyl)-L-methionine p-toluenesulfonate salt is used for the treatment of depression, liver cirrhosis, cholestasis and degenerative joint disease.
Packaging
25, 100, 500 mg in poly bottle
| Colour | white to off-white |
|---|---|
| Quality Level | 200 |
| InChI key | VHPOFDUCFKOUHV-XKGORWRGSA-N |
| InChI | 1S/C15H22N6O5S.C7H8O3S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21;1-6-2-4-7(5-3-6)11(8,9)10/h5-8,10-11,14,22-23H,2-4,16H2, |
| Manufacturer | SIGMA-ALDRICH |
| Composition | p-Toluenesulfonate content, 1.6-4.4 mol/mol |
| Form | powder |
| Assay | ≥80% (spectrophotometric assay), ≥80% (HPLC) |
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