NS 1619, powder

Descriptions

Biochem/physiol Actions

NS 1619 is a selective large conductance Ca²⁺-activated K⁺-channel activator. The compound is known for its vasodilating and anti-proliferative properties. It is studied that NS 1619 can protect cardiac muscle against ischemia and reperfusion injury.

NS-1619 can promote the formation of mitochondrial reactive oxygen species (ROS) in cardiac myocytes. It enhances the formation of ROS in cultured brain slices. NS-1619 has the ability to enhance HO-1 activity in wild-type (WT) animals.

Caution

Photosensitive

Packaging

5, 25 mg in glass bottle

Specifications

Colour	white
InChI key	YLFMCMWKHSDUCT-UHFFFAOYSA-N
InChI	1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)
Manufacturer	SIGMA-ALDRICH
Solubility	DMSO: 5.3 mg/mL, ethanol: 26.6 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.47 mg/mL, 0.1 M NaOH: 5.2 mg/mL, H2O: insoluble
Form	powder