N-Ethylmaleimide, purum p.a., >=99.0% (HPLC)
Application
Reagent for the covalent modification of cysteine residues in proteins.
N-Ethylmaleimide has been used to measure low molecular weight thiols bound to plasma proteins.
Biochem/physiol Actions
Sulfhydryl alkylating agent that inactivates NADP-dependent isocitrate dehydrogenase and many endonucleases.
Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels.
| bp | 210 °C (lit.) |
|---|---|
| Manufacturer | SIGMA-ALDRICH |
| Density | 2.123 g/mL at 25 °C (lit.) |
| Assay | ≥99.0% (HPLC), 98-103%, ≥98% |
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