N-DODECYL- BETA-D-MALTOSIDE (DDM)
Application
n-dodecyl-?-D-maltoside (DDM) has been used to solubilize mitochondrialextracts of fibroblasts to perform one-dimensional blue-native PAGE (BN-PAGE) analysis for assembled oxidative phosphorylation (OXPHOS) complexes.
Biochem/physiol Actions
n-dodecyl-?-D-maltoside (DDM) exhibits biocompatibility and biodegradability. It serves as a facilitator of electron transfer in order to decrease the oxidation potential of 3,4-ethylenedioxythiophene (EDOT). It can also increase the solubility of EDOT in aqueous solution.
General description
n-dodecyl-?-D-maltoside (DDM) is a sugar-based surfactant.
DDM is the most widely used detergent for the isolation and purification of GPCR’;s. In addition, LacY likely favors a higher-energy intermediate periplasmic-open conformation in situ, but collapses to a lower-energy periplasmic-closed conformation in DDM after purification. It is interesting to note that the branched-chain maltoside detergents stabilize LacY in the membrane-embedded form.
Packaging
20 mL Clear Glass Screw Cap Vial (850520P-1g)
30 mL Amber Wide Mouth Screw Cap Glass Bottle (850520P-5g)
125 mL Amber Wide Mouth Glass Bottle with Screw Cap (850520P-25g)
| InChI key | NLEBIOOXCVAHBD-QKMCSOCLSA-N |
|---|---|
| InChI | 1S/C24H46O11/c1-2-3-4-5-6-7-8-9-10-11-12-32-23-21(31)19(29)22(16(14-26)34-23)35-24-20(30)18(28)17(27)15(13-25)33-24/h15-31H,2-14H2,1H3/t15-,16-,17-,18+,19-,20- |
| Form | powder |
| Assay | >99% (contains ﹤2% alpha isomer, TLC) |
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