L-Canavanine sulfate salt, >=99% (TLC), powder

L-Canavanine sulfate salt, >=99% (TLC), powder

Stock Code: 3591042
Manufacturer Part No: C9758-250MG
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£117.00 (exc VAT) per 250MG
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Application

Canavanine sulfate salt has been used:as a translation inhibitor in yeast translation studiesas a component of synthetic complete (SC) drop-out medium for screening yeastfor screening Saccharomyces cerevisiae in canavanine mutation frequency assay

Biochem/physiol Actions

Canavanine is a naturally occurringL-amino acid that competes and interferes withL-arginine-utilizing enzymes due to its structural similarity with thisL-amino acid. It is a selective inhibitor of inducible nitric oxide synthase (iNOS). It acts as a substrate for arginyl tRNA and is incorporated during protein synthesis leading to aberrant canavanyl proteins. Supplementation with canavanine worsens the alfalfa induced Systemic lupus erythematosus (SLE) like syndrome and its incorporation with endosome and proteasome disrupts the antigen processing.

Naturally occurring L-amino acid that interferes with L-arginine-utilizing enzymes due to its structural similarity with this L-amino acid. It is a selective inhibitor of inducible nitric oxide synthase (iNOS).

General description

Canavanine is a homolog of arginine and a non-protein amino acid. It is present in plants like alfalfa, cloves, beans onions and sprouts. Canavanine is synthesized from L-canavaninosuccinic acid and the biosynthetic pathway was first elucidated in jack bean plant.

Packaging

1, 5 g in poly bottle

100, 250 mg in poly bottle

Colourwhite
mp160-165 °C (dec.)
InChI keyMVIPJKVMOKFIEV-DFWYDOINSA-N
InChI1S/C5H12N4O3.H2O4S/c6-3(4(10)11)1-2-12-9-5(7)8;1-5(2,3)4/h3H,1-2,6H2,(H,10,11)(H4,7,8,9);(H2,1,2,3,4)/t3-;/m0./s1
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥99% (TLC)

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