L-2-Aminoadipic acid, >=98% (TLC)
Application
L-2-Aminoadipic acid has been used as a gliotoxin specific for astrocytes in rat. It has also been as an internal standard in the amino acid analysis from fermented food sample.
Biochem/physiol Actions
L-2-Aminoadipic acid inhibits glutamine synthetase and ?-glutamylcysteine synthetase. It modulates glucose metabolism and is present in higher levels in diabetic patients. L-2-Aminoadipic acid plays a key role in suppressing autophagy in C2C12 myotubes.
General description
L-2-Aminoadipic acid/?-aminoadipate is a gliotoxin and is a structural analog of glutamine. It is generated by the catabolism of lysine saccharopine (SAC)/pipecolic acid (PIP) pathways.
Packaging
1, 5 g in poly bottle
100, 250 mg in poly bottle
| Quality Level | 200 |
|---|---|
| mp | 203-205 °C (dec.) (lit.) |
| InChI key | OYIFNHCXNCRBQI-BYPYZUCNSA-N |
| InChI | 1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/t4-/m0/s1 |
| Manufacturer | SIGMA-ALDRICH |
| Form | powder |
| Assay | ≥98% (TLC) |
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