holo-Transferrin bovine, approx.98%

holo-Transferrin bovine, approx.98%

Stock Code: 3593710
Manufacturer Part No: T1408-1G
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£1,190.21 (exc VAT) per 1G
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Analysis Note


Purity by agarose gel electrophoresis.


Application


Holo-Transferrin bovine has been used:as a RPMI-1640 medium supplement for culturing cancer cell lines as a component of visceral fat differentiation medium for the pre-adipocytes primary cell cultureto test the influence of iron-saturation complex on the growth of Malassezia pachydermatisas a standard for strong anion exchange (SAX) reactor measurements


Biochem/physiol Actions


Studies show that treatment of breast cancer cells with holo-transferrin in combination with dihydroartemisinin results in increased tumor cell death due to elevated levels of intracellular ferrous iron.


Holo-Transferrin (holo-Tf) or the iron bound transferrin functions as an iron sequester and is crucial for defense against microbial infections. Transferrin is used as a model system for understanding the kinetics and dynamics of protein structure based interactions. It is a potential candidate for delivery studies for its ability to cross the blood-brain barrier. The interaction of holo-Tf with thrombin is implicated in the pathogenesis of intracerebral hemorrhage. Polymorphisms in the bovine transferrin gene has led to the generation of 10 variant transferrin protein.


General description


Holo-Transferrin is an iron transporting glycoprotein and belongs to metalloprotein class. The gene encoding transferrin is mapped to bovine chromosome 1.


Packaging


1 g in poly bottle


50, 500 mg in poly bottle

Quality Level200
ManufacturerSIGMA-ALDRICH
Technique(s)cell culture - mammalian: suitable
Storage Temp.2-8°C
Formpowder
Assay97-100% (agarose gel electrophoresis)

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