Heregulin-beta1 (EGF Domain) human, >=98% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, ly
Analysis Note
The biological activity is measured by its ability to stimulate the proliferation of human MCF-7 cells grown under serum-free conditions.
Biochem/physiol Actions
Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases. The binding of HRG results in receptor dimerization and receptor trans-autophosphorylation. The phosphorylated receptors recruit cellular signaling proteins, initiating signaling pathways.
| Colour | white |
|---|---|
| Quality Level | 200 |
| Manufacturer | SIGMA-ALDRICH |
| Storage Temp. | −20°C |
| Impurities | endotoxin, tested |
| Form | lyophilized powder |
| Assay | ≥98% (SDS-PAGE) |
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