Heparin sodium salt from porcine intestinal mucosa, endotoxin, free
Application
Heparin sodium salt from porcine intestinal mucosa has been used as a M199 medium supplement used for maintaining human umbilical vein endothelial cells.
Biochem/physiol Actions
Heparin sodium salt is the salt form of heparinic acid and is a polymer classified as a mucopolysaccharide or a glycosoaminoglycan. It is an anticoagulant that produces its major anticoagulant effect by activating antithrombin. Heparin binds to antithrombin III, a naturally occurring plasma protease inhibitor and accelerates significantly the rate at which antithrombin III (AT-III) inhibits coagulation proteases (factor Xa and thrombin). Additionally, it also facilitates the stabilization and regulation of tryptase as an enzymatically active tetramer.
Caution
Not for injection.
Legal Information
E-Toxate is a trademark of Sigma-Aldrich Co. LLC
| Quality Level | 200 |
|---|---|
| Manufacturer | SIGMA-ALDRICH |
| Compatibility | for use with E-Toxate™ |
| Impurities | endotoxin, free |
| Solubility | chloroform: insoluble, acetone: insoluble, alcohol: insoluble, benzene: insoluble, water: soluble 50 g/L, diethyl ether: insoluble |
| Form | powder |
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