Glycine, (based on anhydrous substance), meets analytical specification of Ph. Eur., BP, USP, 99-101
Application
Glycine was used for preparing platelets from whole-blood samples and study the stimulation of cytokine expression in leukocytes. It was used for biochemical and tolerance tests.
Biochem/physiol Actions
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
Glycine has a pivotal role in lowering the plasma lipid levels in diabetic and obese patients by activating the CNS. During brain hypoxia glycine can stabilize the energetics disturbances in brain mitochondria. It also increases the in vitro development of porcine blastocysts when used along with glucose.
| Colour | white |
|---|---|
| Quality Level | 200 |
| mp | 240 °C (dec.) (lit.) |
| pH | 5.9-6.4 (20 °C, 5%) |
| InChI key | DHMQDGOQFOQNFH-UHFFFAOYSA-N |
| InChI | 1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) |
| Manufacturer | SIGMA-ALDRICH |
| Suitability | complies for reaction against H2SO4; in accordance for identity (IR); complies for appearance of solution |
| Impurities | hydrolyzable substances, complies; ≤0.001% heavy metals (as Pb); ≤1.0% ninhydrin-positive substances; organic volatile impurities, complies (GC); residua |
| Solubility | H2O: soluble 25 gm in 100 ml at 25 degrees c; diethyl ether: very slightly soluble; pyridine: soluble 164 parts; H2O: soluble 39.1 gm in |
| Form | crystalline powder |
| Assay | 99-101% (based on anhydrous substance) |
| Loss | ≤0.2% loss on drying, 105 °C, 2 h |
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