Gly-Pro-Arg-Pro amide, >=97% (HPLC)

Gly-Pro-Arg-Pro amide, >=97% (HPLC)

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Amino Acid Sequence

Gly-Pro-Arg-Pro-NH2

Application

Gly-Pro-Arg-Pro amide has been used-as a constituent of buffer during fluid-phase and bound thrombin inhibition assays, to determine the activity of thrombinfor blocking fibrin polymerization and preventing fibrin clot formation in presence of ?-thrombin, in blood obtained from miceduring preparation of human soluble fibrin, to block the polymerization of soluble fibrin

Biochem/physiol Actions

Gly-Pro-Arg-Pro peptide suppresses the early steps of fibrin polymerization. The amide derivative of this peptide prevents the degradation of fibrinogen and fragment D by plasmin, even in the presence of EGTA (ethylene glycol-bis(?-aminoethyl ether)-N,N,N?,N?-tetraacetic acid).

General description

Gly-Pro-Arg-Pro is a peptide that mimics the N-terminal Gly-Pro-Arg region in the a chain of fibrin protein.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Quality Level200
InChI keySCCTZYGEMPQRCV-AVGNSLFASA-N
InChI1S/C18H32N8O4/c19-10-14(27)25-8-3-6-13(25)16(29)24-11(4-1-7-23-18(21)22)17(30)26-9-2-5-12(26)15(20)28/h11-13H,1-10,19H2,(H2,20,28)(H,24,29)(H4,21,22,23)/t11-,1
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
Assay≥97% (HPLC)

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