Gly-Arg-Gly-Asp-Ser, >=97% (HPLC)

Gly-Arg-Gly-Asp-Ser, >=97% (HPLC)

Stock Code: 3591322
Manufacturer Part No: G4391-1MG
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£111.75 (exc VAT) per 1MG
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Amino Acid Sequence

Gly-Arg-Gly-Asp-Ser

Application

Gly-Arg-Gly-Asp-Ser has been used-as an antigen to determine whether integrin ?4 or ?5 hinders the adhesion of day 3 postirradiation thymocytes to thymic epithelial cells, in micefor the treatment of collagen IV-coated dishes to study the role of integrins ?1, ?v, ?1, and ?3 in Sca-1+ progenitor cell differentiation into SMCs (smooth muscle cells) as a blocking peptide for the pre-incubation of Nisseria meningitides strains, to perform blocking experiments to study the interactions between these bacterial strains and fibronectinfor the pre-treatment of EL-4 cells infected by AdCMV-GFP (cytomegalovirus-green fluorescent protein), to study whether interaction with cellular integrins is essential for the transduction of adenovirus

Biochem/physiol Actions

Gly-Arg-Gly-Asp-Ser inhibits metastasis in syngeneic mice or in mice lacking platelet function, when co-injected with B16-Fl0 melanoma cells.

Antagonist of integrin function

General description

Gly-Arg-Gly-Asp-Ser peptide sequence is identical to the cell-binding region of fibronectin protein. Arg-Gly-Asp (RGD) region is found in various proteins, and is crucial for facilitating cell-adhesive activity.

Packaging

1, 5 mg in glass bottle

Quality Level200
InChI keyRGNVSYKVCGAEHK-GUBZILKMSA-N
InChI1S/C17H30N8O9/c18-5-11(27)23-8(2-1-3-21-17(19)20)14(31)22-6-12(28)24-9(4-13(29)30)15(32)25-10(7-26)16(33)34/h8-10,26H,1-7,18H2,(H,22,31)(H,23,27)(H,24,28)(H,25
ManufacturerSIGMA-ALDRICH
CompositionPeptide content, ≥60%
Formpowder
Assay≥97% (HPLC)

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