Gly-Arg-Gly-Asp-Ser, >=97% (HPLC)
Amino Acid Sequence
Gly-Arg-Gly-Asp-Ser
Application
Gly-Arg-Gly-Asp-Ser has been used-as an antigen to determine whether integrin ?4 or ?5 hinders the adhesion of day 3 postirradiation thymocytes to thymic epithelial cells, in micefor the treatment of collagen IV-coated dishes to study the role of integrins ?1, ?v, ?1, and ?3 in Sca-1+ progenitor cell differentiation into SMCs (smooth muscle cells) as a blocking peptide for the pre-incubation of Nisseria meningitides strains, to perform blocking experiments to study the interactions between these bacterial strains and fibronectinfor the pre-treatment of EL-4 cells infected by AdCMV-GFP (cytomegalovirus-green fluorescent protein), to study whether interaction with cellular integrins is essential for the transduction of adenovirus
Biochem/physiol Actions
Gly-Arg-Gly-Asp-Ser inhibits metastasis in syngeneic mice or in mice lacking platelet function, when co-injected with B16-Fl0 melanoma cells.
Antagonist of integrin function
General description
Gly-Arg-Gly-Asp-Ser peptide sequence is identical to the cell-binding region of fibronectin protein. Arg-Gly-Asp (RGD) region is found in various proteins, and is crucial for facilitating cell-adhesive activity.
Packaging
1, 5 mg in glass bottle
| Quality Level | 200 |
|---|---|
| InChI key | RGNVSYKVCGAEHK-GUBZILKMSA-N |
| InChI | 1S/C17H30N8O9/c18-5-11(27)23-8(2-1-3-21-17(19)20)14(31)22-6-12(28)24-9(4-13(29)30)15(32)25-10(7-26)16(33)34/h8-10,26H,1-7,18H2,(H,22,31)(H,23,27)(H,24,28)(H,25 |
| Manufacturer | SIGMA-ALDRICH |
| Composition | Peptide content, ≥60% |
| Form | powder |
| Assay | ≥97% (HPLC) |
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