Gentamicin sulfate from Micromonospora purpurea, approx. 700 U/mg dried material
Application
Used as a selection agent (gentamicin-resistance gene) in molecular biology applications. It inhibits the growth of a wide variety of grampositive and gram-negative microorganisms including strains resistant to tetracycline, chloramphenicol, kanamycin and colistin, particularly strains of Pseudomonas, Proteus, Staphylococcus and Streptococcus.
Biochem/physiol Actions
Mode of Action: Inhibits protein synthesis by binding to L6 protein of 50S ribosomal subunit. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria, and mycoplasma.
General description
Chemical structure: aminoglycoside
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
Packaging
1g, 5g, 25g
Preparation Note
Freely soluble in water, practically insoluble in alcohol and ether.
Unit Definition
1 U corresponds to 1 µg of the USP gentamicin sulfate reference standard
| Colour | white to off-white |
|---|---|
| InChI key | RDEIXVOBVLKYNT-HDZPSJEVSA-N |
| InChI | 1S/C21H43N5O7.C20H41N5O7.C19H39N5O7.H2O4S/c1-9(25-3)13-6-5-10(22)19(31-13)32-16-11(23)7-12(24)17(14(16)27)33-20-15(28)18(26-4)21(2,29)8-30-20;1-8(21)12-5-4-9(2 |
| Manufacturer | SIGMA-ALDRICH |
| Form | powder |
| Loss | ≤18.0% loss on drying |
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