Endothelin 2 human, >=97% (HPLC), powder

Stock Code: 3591157
Manufacturer Part No: E9012-50UG

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Descriptions

Biochem/physiol Actions

Endothelin-2 (ET-2) has a regulatory role in multiple cancer types, such as breast and clear cell renal cell carcinoma (ccRCC). It is overexpressed during early stages of non-metastasized ccRCC, and is thought have a role in the progression of the same. It is a hypoxia-related factor, and might have protective action against cell death in neuronal diseases. It acts as a ligand for ET-A and ET-B receptors, which results in vasoconstriction. A985 polymorphism in this gene is thought play a protective role in cardiovascular diseases, but it acts as a susceptibility factor in atrial fibrillation in hypertrophic cardiomyopathy patients. In neural retina, it suppresses angiogenesis, and facilitates the tip cell state in endothelial cells.

General description

Endothelin-2 (ET-2) is a member of the endothelin family, which also includes ET-1 and ET-3. ET-2 is the human ortholog of mouse and rat vasoactive intestinal contractor (VIC). These peptides are characterized by two disulfide linkages. ET-2 is predominantly expressed in cerebrum, stomach, intestine, ovary, uterus and testis.

Specifications

Colour	white
Quality Level	200
InChI key	MLFJHYIHIKEBTQ-IYRKOGFYSA-N
InChI	1S/C115H160N26O32S4/c1-11-59(9)93(113(170)132-82(115(172)173)41-64-46-120-71-27-19-17-25-68(64)71)141-114(171)94(60(10)12-2)140-105(162)81(44-91(150)151)130-99
Manufacturer	SIGMA-ALDRICH
Form	powder
Assay	≥97% (HPLC)