Cytochrome c from bovine heart, based on Mol. Wt. 12,327 basis, >=95% based on Mol. Wt. 12,327 basis

Cytochrome c from bovine heart, based on Mol. Wt. 12,327 basis, >=95% based on Mol. Wt. 12,327 basis

Stock Code: 3589848
Manufacturer Part No: C3131-100MG
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£438.75 (exc VAT) per 100MG
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Application

Cytochrome c has been identified as an important mediator in apoptotic pathways. The release of mitochondrial cytochrome c into the cytoplasm stimulates apoptosis and is commonly used as an indicator of the apoptotic process in the cell. Investigation on the effect of Paris Saponin I (PS I) on human gastric carcinoma cell growth (SGC7901 cells) have shown an elevated level cytoplasmic cytochrome c. Results are an inhibition of proliferation in SGC7901 cells by inducing mitochondria-dependent apoptosis through cytochrome c.

Biochem/physiol Actions

The ready interconversion of cytochrome c between ferrous and ferric states makes it an efficient biological electron carrier. It plays a vital role in cellular oxidations in both plants and animals. Generally regarded as a universal link in the respiratory chain, it forms the essential electron-bridge between the respirable substrates and oxygen.

Other Notes

View more information on cytochrome c and electron transport at www.sigma-aldrich.com/enzymeexplorer.

Packaging

1 g in poly bottle

10, 50, 100, 250 mg in poly bottle

Preparation Note

Prepared with acetic acid without using TCA.

Quality Level200
ManufacturerSIGMA-ALDRICH
Technique(s)cell culture - mammalian: suitable
Storage Temp.−20°C
Formpowder
Assay≥95% based on Mol. Wt. 12,327 basis

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