Calpastatin Peptide Ac 184-210, >=95% (HPLC)

Stock Code: 3592337
Manufacturer Part No: SCP0063-500UG
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Amino Acid Sequence


Ac-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH2


Application


Calpastatin Peptide Ac 184-210 has been used as the endogenous calpain inhibitor to study its effects on myristoylated alanine-rich C kinase substrate (MARCKS) cleavage in mouse kidney cells. It has also been used as a calpain inhibitor to examine its effects on the formation of DNA-platinum adducts by cisplatin (CDDP) in neuronal cells.


Biochem/physiol Actions


Calpastatin, located in the cytosol, is involved in selective protein cleavage in response to calcium signaling.


Calpastatin, a component of the calpain/calpastatin system, is a calpain (calcium-dependent cysteine protease) inhibitor. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation.

ManufacturerSIGMA-ALDRICH
CompositionPeptide Content, ≥75%
Storage Temp.−20°C
Formlyophilized
Assay≥95% (HPLC)

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