Bombesin acetate salt hydrate, >=97% (HPLC)
Amino Acid Sequence
Glp-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
Application
Bombesin acetate salt hydrate has been used in immunohistochemical methods and food intake measurements.
Biochem/physiol Actions
Tetradecapeptide originally isolated from the skin of the frog Bombina bombina. Bombesin acts at specific brain nuclei to inhibit food intake. It also increases blood glucose levels.
Bombesin/gastrin releasing peptide (BN/GRP) serves as an autocrine growth factor in small cell lung cancer (SCLC). Overexpression of gastrin releasing peptide receptor (GRP-R) is associated with neuroblastoma tumor aggressiveness. GRP-R modulates the important enzymes, that participates in glucose metabolism. Bombesin, a pulmonary growth factor helps to satisfy the conditions for autocrine stimulation.
General description
Gastrin releasing peptide receptor (GRP-R) belongs to the G protein-coupled receptors (GPCR) family. The gene for the gastrin?releasing peptide receptor is located on the short arm of human X chromosome.
Packaging
1, 5 mg in glass bottle
| Quality Level | 200 |
|---|---|
| InChI key | QXZBMSIDSOZZHK-DOPDSADYSA-N |
| InChI | 1S/C71H110N24O18S/c1-34(2)24-47(92-62(105)43(14-11-22-79-71(76)77)89-64(107)45(15-18-52(72)96)90-63(106)44-17-20-55(99)85-44)61(104)81-31-56(100)87-51(28-54(74 |
| Manufacturer | SIGMA-ALDRICH |
| Storage Temp. | −20°C |
| Form | powder |
| Assay | ≥97% (HPLC) |
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