Apamin, from bee venom, >=95% (HPLC)
Amino Acid Sequence
Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2 [Disulfide Bridges: 1-11, 3-15]
Application
Apamin has been used: As a selective inhibitor of small conductance (SKCa) channels in HEK cells.To inhibit endothelium-derived relaxing factor (EDHF) mediated responses.To block small-conductance Ca2-activated K current (ISK) in electrophysiological studies in hyperstriatum ventrale, pars caudalis (HVc) neurons.
Biochem/physiol Actions
Apamin is a neurotoxin and is cytotoxic to erythrocytes. Exposure to apamin leads to hypermotility and convulsions.
The only polypeptide neurotoxin that is known to pass the blood-brain barrier. Blocks ATP-type Ca+2-activated K+ channels.
General description
Apamin is a bee venom component and is strongly basic in nature. It has 18 amino acid residues and two disulphide bonds.
| Quality Level | 200 |
|---|---|
| InChI key | YVIIHEKJCKCXOB-STYWVVQQSA-N |
| InChI | 1S/C79H131N31O24S4/c1-35(2)26-49-70(127)107-51-31-136-135-30-41(81)63(120)105-50(28-57(84)114)71(128)108-53(73(130)99-42(12-7-8-22-80)64(121)96-38(5)77(134)110 |
| Manufacturer | SIGMA-ALDRICH |
| Form | powder |
| Assay | ≥95% (HPLC) |
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