Amyloid beta Protein Fragment 1-40, >=90% (HPLC), powder

Amyloid beta Protein Fragment 1-40, >=90% (HPLC), powder

Stock Code: 3589406
Manufacturer Part No: A1075-.1MG
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Amino Acid Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

Application

Amyloid ? Protein Fragment 1-40 has been used:in the temperature based conformational studies using Fourier transform infrared/differential scanning calorimetry (FT-IR/DSC) studiesas a reference standard in sandwich-type enzyme immunoassay for quantifying amyloid A4 protein in cerebrospinal fluid of patients with head traumaas a component of embryonic stem cell medium to inhibit amyloid deposition in fibroblasts

Biochem/physiol Actions

Amyloid β-protein is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. β-Amyloid peptides (amino acids 1-42 and 1-43) are the major constituents of senile plaques and neurofibrillary tangles that occur in the hippocampus, neocortex, and amygdala of patients with Alzheimer′s disease.

Amyloid ? Protein Fragment 1-40 (A?40) forms cation based ion channels.

General description

Amyloid ? Protein Fragment 1-40 (A?40) is derived from the amyloid-? protein (A?), which is mapped to human chromosome 21q21.3. A?40 is predominantly present in the vascular amyloid deposits. A?40 comprises of C-terminal membrane insertion domain. It shows structural transition from random coil to a ?-helical structure in a water-micelle medium.

Other Notes

Lyophilized from 0.1% TFA in H2O

Reconstitution

For maximal biological activity, dilute the stock in calcium-free PBS to 1?mg/ml and incubate at 37?°C for 4 days.

Colourwhite
Quality Level200
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
Solubility1% acetic acid: 1 mg/mL, saline: insoluble
Formpowder
Assay≥90% (HPLC)

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