Adrenocorticotropic Hormone Fragment 18-39 human, >=97% (HPLC)

Descriptions

Amino Acid Sequence

Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe

Application

Adrenocorticotropic Hormone Fragment 18-39 human has been used for matrix-assisted laser desorption/ionization (MALDI)-TOF-MS and MALDI-MS.

Biochem/physiol Actions

Adrenocorticotropic hormone (ACTH) stimulates the synthesis and release of glucocorticoids and androgens through cAMP-dependent by a G-protein coupled receptor in adrenal gland. Overproduction of ACTH leads to marked skin pigmentation.

Facilitatory effect exerted on paradoxical sleep in the rat: stimulates insulin release.

General description

Adrenocorticotropic hormone (ACTH) is synthesized from its precursor pro-opiomelanocortin (POMC). It is released from anterior pituitary gland in response to corticotropin-releasing hormone (CRH) from hypothalamus. The gene encoding ACTH is localized on human chromosome 2p23.3.

Other Notes

Lyophilized from 0.1% TFA in H₂O

Specifications

Quality Level	200
InChI key	ZYDMZKPAPSZILB-UHFFFAOYSA-N
InChI	1S/C112H165N27O36/c1-56(2)48-72(100(163)125-70(37-41-86(148)149)97(160)133-77(111(174)175)51-63-24-14-11-15-25-63)129-103(166)79-28-20-46-138(79)109(172)75(49-
Manufacturer	SIGMA-ALDRICH
Form	powder
Assay	≥97% (HPLC)