Adrenocorticotropic Hormone Fragment 1-24 human, rat, >=97% (HPLC)

Stock Code: 3589374
Manufacturer Part No: A0298-1MG

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Descriptions

Amino Acid Sequence

Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro

Application

Adrenocorticotropic Hormone Fragment 1-24 human, rat, has been used in corticosterone enzyme immunoassay and to induce color change in frogs.

Biochem/physiol Actions

Activates G proteins.

Adrenocorticotropic hormone (ACTH) activates melanocortin receptor (MC1R to MC5R) and plays a key role in generation of ?-melanocyte-stimulating hormone (?-MSH). The loss of function mutations in ACTH gene is implicated in obesity and red hair. Hypomethylation of POMC promoter region in thymic carcinoids is associated with ectopic adrenocorticotropic hormone syndrome. POMC mutation results in generation of abnormal fusion protein, impairing melanocortin signalling in hypoadrenalism. Dysregulation of ACTH gene transcription impacts metabolic pathways leading to Cushing disease.

General description

Adrenocorticotropic hormone (ACTH), also called proopiomelanocortin (POMC), is a 303-amino acid hormone protein. Proteolysis of ACTH results in active peptides. ACTH is mapped to human chromosome 2p23.3.

The portion of the ACTH sequence that is conserved across species; has ~75% of the potency of ACTH on a molar basis.

Other Notes

Lyophilized from 0.1% TFA in H2O

Specifications

Quality Level	200
InChI key	ZOEFCCMDUURGSE-SQKVDDBVSA-N
InChI	1S/C136H210N40O31S/c1-75(2)109(127(200)154-71-106(181)156-88(31-13-17-52-137)114(187)158-89(32-14-18-53-138)115(188)159-91(35-21-56-149-134(142)143)116(189)164
Manufacturer	SIGMA-ALDRICH
Composition	Peptide content, ≥60%
Form	powder
Assay	≥97% (HPLC)