4-Chloro-L-phenylalanine,
Application
4-Chloro-L-phenylalanine (L-PCPA) has been used: to block serotonin synthesis by inhibiting tryptophan hydroxylase (TPH) to study its behavioral and electrographic effects on epileptic senegalese baboon (Papio papio) as a substrate for Chromobacterium violaceum phenylalanine hydroxylaseto incubate sea urchin embryos for immunohistochemistry
Biochem/physiol Actions
4-Chloro-L-phenylalanine (L-PCPA) inhibits the synthesis of 5-hydroxytryptamine (5-HT). 4-Chloro-DL-phenylalanine (PCPA) depletes the serotonin levels in the brain by its inhibitory effect on tryptophan hydroxylase (Tph). Studies support the protective effects of PCPA against monocrotaline-induced pulmonary vascular remodeling as well as in lung inflammation.
Tryptophan hydroxylase inhibitor.
Packaging
1 g in glass bottle
250 mg in glass bottle
Bottomless glass bottle. Contents are inside inserted fused cone.
| Quality Level | 200 |
|---|---|
| mp | 263 °C (dec.) (lit.) |
| InChI key | NIGWMJHCCYYCSF-QMMMGPOBSA-N |
| InChI | 1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)/t8-/m0/s1 |
| Manufacturer | SIGMA-ALDRICH |
| Storage Temp. | −20°C |
| Form | powder |
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