3-Iodo-L-tyrosine,

Stock Code: 3591560
Manufacturer Part No: I8250-5G
Order Now for 21 day delivery
£410.89 (exc VAT) per 5G
Quantity: - +

Application

3-Iodo-L-tyrosine has been used as an inhibitor for tyrosine hydroxylase enzyme in Drosophila and silkworm pupae.

Biochem/physiol Actions

TH (tyrosine 3-hydroxylase) is responsible for catalyzing the first step of the noradrenergic biosynthesis pathway. Mutations in TH are associated with tyrosine hydroxylase deficiency, leading to conditions such as infantile parkinsonism and DOPA (dopamine)-responsive dystonia as well as encephalopathy with perinatal onset.

3-iodotyrosine (3-IY) inhibits tyrosine hydroxylase that catalyzes levodopa (L-DOPA) formation from tyrosine. Iodotyrosine deiodinase enzyme deficiency leads to elevated levels of 3-IY in serum and urine in severe hypothyroidism and goiter.

Tyrosine hydroxylase inhibitor.

General description

Iodotyrosine coupled with di-iodotyrosine results in the synthesis of 3,5,3?-tri-iodothyronine (T3) or 3,3?,5?-tri-iodothyronine (rT3).

Packaging

1, 5, 25 g in poly bottle

Quality Level200
mp210 °C (dec.) (lit.)
InChI keyUQTZMGFTRHFAAM-ZETCQYMHSA-N
InChI1S/C9H10INO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1
ManufacturerSIGMA-ALDRICH
Impurities~5% tyrosine
Solubilitydilute aqueous acid: soluble

There are no downloads for this product.