3-Iodo-L-tyrosine,
Application
3-Iodo-L-tyrosine has been used as an inhibitor for tyrosine hydroxylase enzyme in Drosophila and silkworm pupae.
Biochem/physiol Actions
TH (tyrosine 3-hydroxylase) is responsible for catalyzing the first step of the noradrenergic biosynthesis pathway. Mutations in TH are associated with tyrosine hydroxylase deficiency, leading to conditions such as infantile parkinsonism and DOPA (dopamine)-responsive dystonia as well as encephalopathy with perinatal onset.
3-iodotyrosine (3-IY) inhibits tyrosine hydroxylase that catalyzes levodopa (L-DOPA) formation from tyrosine. Iodotyrosine deiodinase enzyme deficiency leads to elevated levels of 3-IY in serum and urine in severe hypothyroidism and goiter.
Tyrosine hydroxylase inhibitor.
General description
Iodotyrosine coupled with di-iodotyrosine results in the synthesis of 3,5,3?-tri-iodothyronine (T3) or 3,3?,5?-tri-iodothyronine (rT3).
Packaging
1, 5, 25 g in poly bottle
| Quality Level | 200 |
|---|---|
| mp | 210 °C (dec.) (lit.) |
| InChI key | UQTZMGFTRHFAAM-ZETCQYMHSA-N |
| InChI | 1S/C9H10INO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1 |
| Manufacturer | SIGMA-ALDRICH |
| Impurities | ~5% tyrosine |
| Solubility | dilute aqueous acid: soluble |
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