Phosphoramidon disodium salt, >=97% (TLC)

Stock Code: 3577900
Manufacturer Part No: R7385-25MG

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Descriptions

Application

Identification of phosphoramidon as a metallo-endopeptidase inhibitor was used to characterize endothelin converting enzyme as a metallo-endopeptidase. Phosphoramidon increases the production of β-amyloid protein, but not amyloid precursor protein, indicating that abnormal amyloid processing in Alzheimer′s disease may be carried out by a metallo-endopeptidase.

Phosphoramidon disodium salt has been used:as the neprilysin (NEP) inhibitor: in amyloid beta (A?) uptake and degradationto study its effect on keratinase activityto treat primary microglia from wild-type mice

Biochem/physiol Actions

Phosphoramidon is a potent inhibitor of thermolysin and other metallo-endopeptidases. It trongly inhibits mammalian enkephalinase and it does not inhibit trypsin, papain, chymotrypsin or pepsin. It weakly inhibits collagenase.

Phosphoramidon can inhibit ZMPSTE24, an integral membrane protein zinc metalloprotease. It is capable of blocking thermolysin.

General description

Phosphoramidon [N-(?-rhamnopyranosyl-oxyhydroxyphosphinyl)-Leu-Trp] is a competitive inhibitor of several soluble zinc metalloproteases. Phosphoramidate is produced naturally by Streptomycestanashiensis.

Packaging

0.5, 1, 5 mg in glass bottle

10, 25 mg in poly bottle

Specifications

Quality Level	200
InChI key	OQKHVXFOYFBMDJ-ODIUWQMJSA-L
InChI	1S/C23H34N3O10P.2Na/c1-11(2)8-16(26-37(33,34)36-23-20(29)19(28)18(27)12(3)35-23)21(30)25-17(22(31)32)9-13-10-24-15-7-5-4-6-14(13)15;;/h4-7,10-12,16-20,23-24,27
Manufacturer	SIGMA-ALDRICH
Solubility	H2O: 50 mg/mL
Form	powder
Assay	≥97% (HPLC)