N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone, elastase inhibitor

Application

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone has been used as an elastase specific inhibitor.

Biochem/physiol Actions

Irreversible inhibitor of human leukocyte and neutrophil elastase.

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone acts as a competitive inhibitor of human leukocyte elastase (HLE).

General description

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone is a tetrapeptide, cell-permeable and non-cytotoxic inhibitor.

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Code	Description	Quality Level	mp	InChI key	InChI	Manufacturer	Solubility	Form	Assay	Price	Quantity
3577837	N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone, elastase inhibitor	200	159 °C	PJGDFLJMBAYGGC-XLPNERPQSA-N	1S/C22H35ClN4O7/c1-12(2)19(16(28)11-23)26-21(32)15-7-6-10-27(15)22(33)14(4)25-20(31)13(3)24-17(29)8-9-18(30)34-5/h12-15,19H,6-11H2,1-5H3,(H,24,29)(H,25,31)(H,2	SIGMA-ALDRICH	methanol: 50 mg/mL, clear, colorless	powder	≥98% (TLC)	£424.82 (exc VAT) per 10MG	- +
3577838	N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone, elastase inhibitor	200	159 °C	PJGDFLJMBAYGGC-XLPNERPQSA-N	1S/C22H35ClN4O7/c1-12(2)19(16(28)11-23)26-21(32)15-7-6-10-27(15)22(33)14(4)25-20(31)13(3)24-17(29)8-9-18(30)34-5/h12-15,19H,6-11H2,1-5H3,(H,24,29)(H,25,31)(H,2	SIGMA-ALDRICH	methanol: 50 mg/mL, clear, colorless	powder	≥98% (TLC)	£643.50 (exc VAT) per 25MG	- +
3577839	N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone, elastase inhibitor	200	159 °C	PJGDFLJMBAYGGC-XLPNERPQSA-N	1S/C22H35ClN4O7/c1-12(2)19(16(28)11-23)26-21(32)15-7-6-10-27(15)22(33)14(4)25-20(31)13(3)24-17(29)8-9-18(30)34-5/h12-15,19H,6-11H2,1-5H3,(H,24,29)(H,25,31)(H,2	SIGMA-ALDRICH	methanol: 50 mg/mL, clear, colorless	powder	≥98% (TLC)	£199.18 (exc VAT) per 5MG	- +

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