5-Fluoro-2-deoxyuridine, thymidylate synthase inhibitor

5-Fluoro-2-deoxyuridine, thymidylate synthase inhibitor

Application

5-Fluoro-2?-deoxyuridine has been used as a mitotic inhibitor in schwann cell proliferation, glia proliferation and nonneuronal cells in dorsal root ganglion cultures.

Biochem/physiol Actions

Antineoplastic drug that acts as a potent inhibitor of thymidylate synthetase Resistance to FUdR can develop in cancer cell cultures, among other means, by low-level Mycoplasma infection.

General description

5-Fluoro-2?-deoxyuridine, also called floxuridine elicits DNA-directed cytotoxicity in cancer cells. Floxuridine is effective for treating liver cancer and eliminating virulence of Staphylococcus aureus. Dipeptide prodrugs combination of floxuridine with gemcitabine are more cell permeable and display enhanced anti-proliferative activity. Floxuridine is effective on solid tumours and advanced stage cancers.

Packaging

1 g in poly bottle

100, 250 mg in poly bottle

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Code Description Quality Level mp InChI key InChI Manufacturer Form Assay Price Quantity
3577769 5-Fluoro-2-deoxyuridine, thymidylate synthase inhibitor 200 148 °C (lit.) ODKNJVUHOIMIIZ-RRKCRQDMSA-N 1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1 SIGMA-ALDRICH powder ≥99% (HPLC)
£331.50 (exc VAT) per 100MG
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3577770 5-Fluoro-2-deoxyuridine, thymidylate synthase inhibitor 200 148 °C (lit.) ODKNJVUHOIMIIZ-RRKCRQDMSA-N 1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1 SIGMA-ALDRICH powder ≥99% (HPLC)
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3577771 5-Fluoro-2-deoxyuridine, thymidylate synthase inhibitor 200 148 °C (lit.) ODKNJVUHOIMIIZ-RRKCRQDMSA-N 1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1 SIGMA-ALDRICH powder ≥99% (HPLC)
£753.54 (exc VAT) per 250MG
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