6-Thioguanine, >=98%

6-Thioguanine, >=98%

Application

6-Thioguanine has been used:to induce autophagy and apoptosis in colorectal cancer cell lines HCT116as a selection marker in the mutation and survival assay in chinese hamster lung fibroblasts culture V79as a selection marker in clonogenic Lung metastasis assay of 4T1-luc cells

Biochem/physiol Actions

Ribosylated and phosphorylated by the same pathway as natural purine bases; as the nucleotide, inhibits a variety of cellular processes involved in nucleic acid synthesis. Has a long history as an effective treatment of leukemia.

Antimetabolite used in the treatment of leukemias. Competes with hypoxanthine and guanine for the enzyme hypoxanthine-guanine phosphoribosyltransferase, which catalzyes a critical step in the generation of purine nucleotides.

General description

6-Thioguanine is a variant of guanine with hydrogen bonding at the N-7 of the purine ring. Its association with cytosine alters the dimension of the base stacking. 6-Thioguanine usage in treating inflammatory bowel disease (IBD) contributes to nodular regenerative hyperplasia (NRH) in the liver.

Packaging

100, 250, 500 mg in glass bottle

1, 5 g in glass bottle

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Code Description Quality Level mp InChI key InChI Manufacturer Form Assay Price
3577608 6-Thioguanine, >=98% 200 ≥300 °C (lit.) WYWHKKSPHMUBEB-UHFFFAOYSA-N 1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) SIGMA-ALDRICH powder ≥98%
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3577609 6-Thioguanine, >=98% 200 ≥300 °C (lit.) WYWHKKSPHMUBEB-UHFFFAOYSA-N 1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) SIGMA-ALDRICH powder ≥98%
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3577610 6-Thioguanine, >=98% 200 ≥300 °C (lit.) WYWHKKSPHMUBEB-UHFFFAOYSA-N 1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) SIGMA-ALDRICH powder ≥98%
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3577611 6-Thioguanine, >=98% 200 ≥300 °C (lit.) WYWHKKSPHMUBEB-UHFFFAOYSA-N 1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) SIGMA-ALDRICH powder ≥98%
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3577612 6-Thioguanine, >=98% 200 ≥300 °C (lit.) WYWHKKSPHMUBEB-UHFFFAOYSA-N 1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) SIGMA-ALDRICH powder ≥98%
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