Ribavirin, antiviral

Ribavirin, antiviral

Biochem/physiol Actions

Antiviral agent used against a wide variety of human viral infections, in particular, chronic hepatitis C, HIV, and adenovirus. Its metabolite, ribavirin 5′-phosphate, is an inhibitor of inosine monophosphate (IMP) dehydrogenase, but many other mechanisms of action are also supported with experimental evidence.

Antiviral agent. Its metabolite, ribavirin 5′-phosphate, is an inhibitor of inosine monophosphate (IMP) dehydrogenase. Used to inhibit purine (GTP pools) biosynthesis at the level of inosine monophosphate (IMP) dehydrogenase and as a precursor to the di- and tri-phosphates which inhibit viral RNA-dependent RNA polymerases.

General description

Analog of the imidazole nucleotide intermediates in purine nucleotide biosynthesis.

Chemical structure: nucleoside

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. R9644.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Packaging

50 mg in glass bottle

10 mg in poly bottle

No detailed specifications are available for this product.

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Code Description Quality Level InChI key InChI Manufacturer Form Assay Price Quantity
3577906 Ribavirin, antiviral 200 IWUCXVSUMQZMFG-AFCXAGJDSA-N 1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1 SIGMA-ALDRICH powder ≥98% (TLC)
£92.35 (exc VAT) per 10MG
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3577907 Ribavirin, antiviral 200 IWUCXVSUMQZMFG-AFCXAGJDSA-N 1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1 SIGMA-ALDRICH powder ≥98% (TLC)
£313.39 (exc VAT) per 50MG
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