Ebselen, cysteine modifier

Ebselen, cysteine modifier

Application

Ebselen has been used as a: voltage-dependent calcium channels (VDCCs) blockerglutathione peroxidase mimetic to test its inhibitory effect on contraction-mediated deoxy glucose (2-DG) uptake in mouseextensor digitorum longus (fast-twitch) muscleglucocerebrosidase inhibitorhepatitis C virus helicase inhibitor

Biochem/physiol Actions

An organo-selenium compound possessing antioxidant properties. Inhibits mammalian lipoxygenases in the absence of thiol groups, and glutathione S-transferase and papain via the interaction with cysteine residues. Also inhibits indoleamine 2,3-dioxygenase by covalently modifying a cysteine residue, the effect being reversible with dithiothreitol. Inhibits oxidation of low density lipoproteins (LDL).

Ebselen, a glutathione-peroxidase-mimic, elicits anti-inflammatory activity. It also has anti-atherosclerotic functionality. Ebselen displays antibacterial action on) multidrug-resistant Staphylococcus aureus (MRSA) infections and could be a potential therapeutic target for treating MRSA based skin infection. It is regarded as neuroprotective agent and elicits chemopreventive functionality in inflammation-associated carcinogenesis.

General description

Ebselen is a sympathomimetic amine.

Packaging

100 mg in glass bottle

25 mg in poly bottle

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Code Description Quality Level mp InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3577734 Ebselen, cysteine modifier 200 176-182 °C DYEFUKCXAQOFHX-UHFFFAOYSA-N 1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H SIGMA-ALDRICH chloroform: 19.60-20.40 mg/mL, clear, yellow powder ≥98% (TLC)
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3577735 Ebselen, cysteine modifier 200 176-182 °C DYEFUKCXAQOFHX-UHFFFAOYSA-N 1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H SIGMA-ALDRICH chloroform: 19.60-20.40 mg/mL, clear, yellow powder ≥98% (TLC)
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