Phosphoramidon disodium salt, >=97% (TLC)

Phosphoramidon disodium salt, >=97% (TLC)

Application

Identification of phosphoramidon as a metallo-endopeptidase inhibitor was used to characterize endothelin converting enzyme as a metallo-endopeptidase. Phosphoramidon increases the production of β-amyloid protein, but not amyloid precursor protein, indicating that abnormal amyloid processing in Alzheimer′s disease may be carried out by a metallo-endopeptidase.

Phosphoramidon disodium salt has been used:as the neprilysin (NEP) inhibitor: in amyloid beta (A?) uptake and degradationto study its effect on keratinase activityto treat primary microglia from wild-type mice

Biochem/physiol Actions

Phosphoramidon is a potent inhibitor of thermolysin and other metallo-endopeptidases. It trongly inhibits mammalian enkephalinase and it does not inhibit trypsin, papain, chymotrypsin or pepsin. It weakly inhibits collagenase.

Phosphoramidon can inhibit ZMPSTE24, an integral membrane protein zinc metalloprotease. It is capable of blocking thermolysin.

General description

Phosphoramidon [N-(?-rhamnopyranosyl-oxyhydroxyphosphinyl)-Leu-Trp] is a competitive inhibitor of several soluble zinc metalloproteases. Phosphoramidate is produced naturally by Streptomycestanashiensis.

Packaging

0.5, 1, 5 mg in glass bottle

10, 25 mg in poly bottle

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Code Description Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3577897 Phosphoramidon disodium salt, >=97% (TLC) 200 OQKHVXFOYFBMDJ-ODIUWQMJSA-L 1S/C23H34N3O10P.2Na/c1-11(2)8-16(26-37(33,34)36-23-20(29)19(28)18(27)12(3)35-23)21(30)25-17(22(31)32)9-13-10-24-15-7-5-4-6-14(13)15;;/h4-7,10-12,16-20,23-24,27 SIGMA-ALDRICH H2O: 50 mg/mL powder ≥97% (HPLC)
£104.46 (exc VAT) per EACH
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3577898 Phosphoramidon disodium salt, >=97% (TLC) 200 OQKHVXFOYFBMDJ-ODIUWQMJSA-L 1S/C23H34N3O10P.2Na/c1-11(2)8-16(26-37(33,34)36-23-20(29)19(28)18(27)12(3)35-23)21(30)25-17(22(31)32)9-13-10-24-15-7-5-4-6-14(13)15;;/h4-7,10-12,16-20,23-24,27 SIGMA-ALDRICH H2O: 50 mg/mL powder ≥97% (HPLC)
£746.57 (exc VAT) per 10MG
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3577899 Phosphoramidon disodium salt, >=97% (TLC) 200 OQKHVXFOYFBMDJ-ODIUWQMJSA-L 1S/C23H34N3O10P.2Na/c1-11(2)8-16(26-37(33,34)36-23-20(29)19(28)18(27)12(3)35-23)21(30)25-17(22(31)32)9-13-10-24-15-7-5-4-6-14(13)15;;/h4-7,10-12,16-20,23-24,27 SIGMA-ALDRICH H2O: 50 mg/mL powder ≥97% (HPLC)
£182.46 (exc VAT) per 1MG
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3577900 Phosphoramidon disodium salt, >=97% (TLC) 200 OQKHVXFOYFBMDJ-ODIUWQMJSA-L 1S/C23H34N3O10P.2Na/c1-11(2)8-16(26-37(33,34)36-23-20(29)19(28)18(27)12(3)35-23)21(30)25-17(22(31)32)9-13-10-24-15-7-5-4-6-14(13)15;;/h4-7,10-12,16-20,23-24,27 SIGMA-ALDRICH H2O: 50 mg/mL powder ≥97% (HPLC)
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3577901 Phosphoramidon disodium salt, >=97% (TLC) 200 OQKHVXFOYFBMDJ-ODIUWQMJSA-L 1S/C23H34N3O10P.2Na/c1-11(2)8-16(26-37(33,34)36-23-20(29)19(28)18(27)12(3)35-23)21(30)25-17(22(31)32)9-13-10-24-15-7-5-4-6-14(13)15;;/h4-7,10-12,16-20,23-24,27 SIGMA-ALDRICH H2O: 50 mg/mL powder ≥97% (HPLC)
£380.25 (exc VAT) per 5MG
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