P1,P5-Di(adenosine-5) pentaphosphate trilithium salt, >=95%, powder

Stock Code: 3577712
Manufacturer Part No: D6392-10MG

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Descriptions

Application

P1,P5-Di(adenosine-5?) pentaphosphate trilithium salt has been used as a adenylate kinase inhibitor and as a component of pre-AMPPNP rigor solution for treating muscle fibres.

Biochem/physiol Actions

A diadenosine polyphosphate stored in secretory granules of thrombocytes, chromaffin and neuronal cells. After release into the extracellular space, it affects a variety of biological activities in a wide range of target tissues. In the nervous system it acts through various purinergic receptors. It also activates 5′-nucleotidase and inhibits adenosine kinase activity in vitro. Ap5A is metabolized by soluble enzymes in the blood plasma and by membrane-bound ectoenzymes of a number of cell types including endothelial and smooth muscle cells. In cardiac muscle, pM to nM concentrations significantly increase the open-probability of ryanodine-receptor (RyR2) gates, with prolonged action due to slow dissociation from the receptor.

Packaging

10, 50 mg in poly bottle

Specifications

Colour	white to off-white
Quality Level	200
InChI key	BFBDFBHROZLGEG-JJCYRVQFSA-K
InChI	1S/C20H29N10O22P5.3Li/c21-15-9-17(25-3-23-15)29(5-27-9)19-13(33)11(31)7(47-19)1-45-53(35,36)49-55(39,40)51-57(43,44)52-56(41,42)50-54(37,38)46-2-8-12(32)14(34)
Manufacturer	SIGMA-ALDRICH
Form	powder
Assay	≥95%