Leflunomide, Immunosuppressant
Application
By virtue of its immunosuppressant effects, leflunomide has found use in organ transplantation and treatment of rheumatoid arthritis and other autoimmune diseases.
Biochem/physiol Actions
Immunosuppressive; inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is believed to inhibit dihydroorotate dehydrogenase (in the de novo pyrimidine synthesis pathway) as well as several protein tyrosine kinases.
Packaging
25, 100 mg in poly bottle
| Quality Level | 200 |
|---|---|
| mp | 166.5 °C |
| InChI key | VHOGYURTWQBHIL-UHFFFAOYSA-N |
| InChI | 1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18) |
| Manufacturer | SIGMA-ALDRICH |
| Form | powder |
| Assay | ≥98% (TLC) |
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