Leflunomide, Immunosuppressant

Stock Code: 3577830
Manufacturer Part No: L5025-100MG

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Descriptions

Application

By virtue of its immunosuppressant effects, leflunomide has found use in organ transplantation and treatment of rheumatoid arthritis and other autoimmune diseases.

Biochem/physiol Actions

Immunosuppressive; inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is believed to inhibit dihydroorotate dehydrogenase (in the de novo pyrimidine synthesis pathway) as well as several protein tyrosine kinases.

Packaging

25, 100 mg in poly bottle

Specifications

Quality Level	200
mp	166.5 °C
InChI key	VHOGYURTWQBHIL-UHFFFAOYSA-N
InChI	1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)
Manufacturer	SIGMA-ALDRICH
Form	powder
Assay	≥98% (TLC)