L-Buthionine-sulfoximine, >=97% (TLC)

L-Buthionine-sulfoximine, >=97% (TLC)

Stock Code: 3577642
Manufacturer Part No: B2515-5G
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Application


Used to induce experimental glutathione deficiency, to investigate roles of glutathione in cellular processes.


L-Buthionine-sulfoximine has been used:as a selective activator for the induction of ferroptosis in rat apoptotic cellsas an inhibitor of ?-glutamylcysteine synthetase to study its effects on the viability and effectiveness of microspore embryogenesis (ME) induction in triticale and barleyas a glutathione synthesis blocker to study its effects on auranofin (AFN)-mediated interleukin-1? expression in murine alveolar macrophages


Biochem/physiol Actions


Blocks cellular resistance to chemotherapy by inhibiting γ-glutamylcysteine synthetase, a key enzyme in glutathione biosynthesis. Used to induce experimental glutathione deficiency, to investigate roles of glutathione in cellular processes.


Packaging


1, 5 g in poly bottle


500 mg in poly bottle

Quality Level200
mp224-226 °C
InChI keyKJQFBVYMGADDTQ-CVSPRKDYSA-N
InChI1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)/t7-,14?/m0/s1
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥97% (TLC)

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