L-Buthionine-sulfoximine, >=97% (TLC)
Application
Used to induce experimental glutathione deficiency, to investigate roles of glutathione in cellular processes.
L-Buthionine-sulfoximine has been used:as a selective activator for the induction of ferroptosis in rat apoptotic cellsas an inhibitor of ?-glutamylcysteine synthetase to study its effects on the viability and effectiveness of microspore embryogenesis (ME) induction in triticale and barleyas a glutathione synthesis blocker to study its effects on auranofin (AFN)-mediated interleukin-1? expression in murine alveolar macrophages
Biochem/physiol Actions
Blocks cellular resistance to chemotherapy by inhibiting γ-glutamylcysteine synthetase, a key enzyme in glutathione biosynthesis. Used to induce experimental glutathione deficiency, to investigate roles of glutathione in cellular processes.
Packaging
1, 5 g in poly bottle
500 mg in poly bottle
| Quality Level | 200 |
|---|---|
| mp | 224-226 °C |
| InChI key | KJQFBVYMGADDTQ-CVSPRKDYSA-N |
| InChI | 1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)/t7-,14?/m0/s1 |
| Manufacturer | SIGMA-ALDRICH |
| Form | powder |
| Assay | ≥97% (TLC) |
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