Filipin III from Streptomyces filipinensis, >=85% (HPLC)

Stock Code: 3577780
Manufacturer Part No: F4767-1MG

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Descriptions

Application

Filipin has been used in a double staining procedure as a probe for the detection of lipoproteins in polyacrylamide gel and immobilized on nitrocellulose membranes. It is also widely used to localize and quantitate unesterified cholesterol by virtue of a specific fluorescent complex.

Biochem/physiol Actions

Filipin is a polyene macrolide antibiotic and antifungal. The antifungal mechanism of action may be due to altering membrane permeability and associated functions by binding to membrane sterols. Filipin inhibits prion protein (PrP) endocytosis and causes the release of PrP from the plasma membrane.

Other Notes

Filipin III is the major component of 8 isomeric components in filipin.

Packaging

1, 5 mg in glass bottle

Specifications

Quality Level	300
mp	163-180 °C
InChI key	IMQSIXYSKPIGPD-BWJOQPJXSA-N
InChI	1S/C35H58O11/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45/h6-10,12-15,2
Manufacturer	SIGMA-ALDRICH
Form	powder
Assay	≥85% (HPLC)