Ebselen, cysteine modifier

Ebselen, cysteine modifier

Stock Code: 3577734
Manufacturer Part No: E3520-100MG
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Application


Ebselen has been used as a: voltage-dependent calcium channels (VDCCs) blockerglutathione peroxidase mimetic to test its inhibitory effect on contraction-mediated deoxy glucose (2-DG) uptake in mouseextensor digitorum longus (fast-twitch) muscleglucocerebrosidase inhibitorhepatitis C virus helicase inhibitor


Biochem/physiol Actions


An organo-selenium compound possessing antioxidant properties. Inhibits mammalian lipoxygenases in the absence of thiol groups, and glutathione S-transferase and papain via the interaction with cysteine residues. Also inhibits indoleamine 2,3-dioxygenase by covalently modifying a cysteine residue, the effect being reversible with dithiothreitol. Inhibits oxidation of low density lipoproteins (LDL).


Ebselen, a glutathione-peroxidase-mimic, elicits anti-inflammatory activity. It also has anti-atherosclerotic functionality. Ebselen displays antibacterial action on) multidrug-resistant Staphylococcus aureus (MRSA) infections and could be a potential therapeutic target for treating MRSA based skin infection. It is regarded as neuroprotective agent and elicits chemopreventive functionality in inflammation-associated carcinogenesis.


General description


Ebselen is a sympathomimetic amine.


Packaging


100 mg in glass bottle


25 mg in poly bottle

Quality Level200
mp176-182 °C
InChI keyDYEFUKCXAQOFHX-UHFFFAOYSA-N
InChI1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H
ManufacturerSIGMA-ALDRICH
Solubilitychloroform: 19.60-20.40 mg/mL, clear, yellow
Formpowder
Assay≥98% (TLC)

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