Ebselen, cysteine modifier
Application
Ebselen has been used as a: voltage-dependent calcium channels (VDCCs) blockerglutathione peroxidase mimetic to test its inhibitory effect on contraction-mediated deoxy glucose (2-DG) uptake in mouseextensor digitorum longus (fast-twitch) muscleglucocerebrosidase inhibitorhepatitis C virus helicase inhibitor
Biochem/physiol Actions
An organo-selenium compound possessing antioxidant properties. Inhibits mammalian lipoxygenases in the absence of thiol groups, and glutathione S-transferase and papain via the interaction with cysteine residues. Also inhibits indoleamine 2,3-dioxygenase by covalently modifying a cysteine residue, the effect being reversible with dithiothreitol. Inhibits oxidation of low density lipoproteins (LDL).
Ebselen, a glutathione-peroxidase-mimic, elicits anti-inflammatory activity. It also has anti-atherosclerotic functionality. Ebselen displays antibacterial action on) multidrug-resistant Staphylococcus aureus (MRSA) infections and could be a potential therapeutic target for treating MRSA based skin infection. It is regarded as neuroprotective agent and elicits chemopreventive functionality in inflammation-associated carcinogenesis.
General description
Ebselen is a sympathomimetic amine.
Packaging
100 mg in glass bottle
25 mg in poly bottle
| Quality Level | 200 |
|---|---|
| mp | 176-182 °C |
| InChI key | DYEFUKCXAQOFHX-UHFFFAOYSA-N |
| InChI | 1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H |
| Manufacturer | SIGMA-ALDRICH |
| Solubility | chloroform: 19.60-20.40 mg/mL, clear, yellow |
| Form | powder |
| Assay | ≥98% (TLC) |
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