Cytosine beta-D-arabinofuranoside hydrochloride, crystalline
Application
Cytosine ?-D-arabinofuranoside hydrochloride has been used in fetal bovine serum supplemented Dulbecco?s modified eagle medium (FBS-DMEM) and B27/neurobasal-A medium to inhibit the growth of glial cells. It has also been used to inhibit astrocyte proliferation in embryonic spinal cord neurons.
Biochem/physiol Actions
Ara-C is phosphorylated to Ara-CTP and is incorporatee into DNA. It inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation, and ultimately induces apoptosis via the PKC signaling pathway. Does not inhibit RNA synthesis. Anti-leukemia agent.
Packaging
100, 500 mg in glass bottle
1, 5 g in glass bottle
25 mg in poly bottle
| Quality Level | 200 |
|---|---|
| mp | 197-198 °C (lit.) |
| InChI key | KCURWTAZOZXKSJ-JBMRGDGGSA-N |
| InChI | 1S/C9H13N3O5.ClH/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8;/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16);1H/t4-,6-,7+,8-;/m1./s1 |
| Manufacturer | SIGMA-ALDRICH |
| Storage Temp. | 2-8°C |
| Form | crystalline |
There are no downloads for this product.
