Cytosine beta-D-arabinofuranoside hydrochloride, crystalline

Cytosine beta-D-arabinofuranoside hydrochloride, crystalline

Stock Code: 3577680
Manufacturer Part No: C6645-100MG
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£85.80 (exc VAT) per 100MG
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Application


Cytosine ?-D-arabinofuranoside hydrochloride has been used in fetal bovine serum supplemented Dulbecco?s modified eagle medium (FBS-DMEM) and B27/neurobasal-A medium to inhibit the growth of glial cells. It has also been used to inhibit astrocyte proliferation in embryonic spinal cord neurons.


Biochem/physiol Actions


Ara-C is phosphorylated to Ara-CTP and is incorporatee into DNA. It inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation, and ultimately induces apoptosis via the PKC signaling pathway. Does not inhibit RNA synthesis. Anti-leukemia agent.


Packaging


100, 500 mg in glass bottle


1, 5 g in glass bottle


25 mg in poly bottle

Quality Level200
mp197-198 °C (lit.)
InChI keyKCURWTAZOZXKSJ-JBMRGDGGSA-N
InChI1S/C9H13N3O5.ClH/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8;/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16);1H/t4-,6-,7+,8-;/m1./s1
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
Formcrystalline

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