Cyclosporin A, >=98.5%
Application
Cyclosporin A is used for immunosuppressive studies .
Biochem/physiol Actions
A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.
General description
Chemical structure: peptide
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.Storage class (TRGS 510): Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects.
Packaging
25, 100 mg in glass bottle
Bottomless glass bottle. Contents are inside inserted fused cone.
| Colour | white to off-white |
|---|---|
| InChI key | PMATZTZNYRCHOR-CGLBZJNRSA-N |
| InChI | 1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41( |
| Manufacturer | SIGMA-ALDRICH |
| Form | powder |
| Assay | 97.0-101.5% (on dried basis) |
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